Advanced Synthetic Methodologies

Explore breakthrough research articles, reaction mechanisms, and innovative strategies in organic synthesis.

Research Articles

Beyond the Break: How Chemists Are Rewriting the Rules of Organic Synthesis

Exploring C-H transformations of aldehyde hydrazones through radical strategies and transition metal catalysis for innovative organic synthesis

Lillian Cooper
Nov 03, 2025

How a Chemical Tag Team Tames the Tough Bonds of Life

Discover how dinuclear copper-guanidine complexes mimic enzymes to break strong C-H bonds using cooperative chemistry for pharmaceutical and green chemistry applications.

Zoe Hayes
Oct 31, 2025

Molecular Thermostat: How Temperature Controls Selective Carbon-Hydrogen Bond Transformation

Discover how temperature acts as a precise molecular switch to control selective C–H bond functionalization through palladium catalysis.

Aurora Long
Oct 29, 2025

Unlocking Quinoline's Potential: The Green Chemistry Revolution

Comprehensive review of regioselective quinoline functionalization through C-H activation - a revolutionary approach in sustainable drug discovery and materials science

Connor Hughes
Oct 20, 2025

PNNP-Ligated Ruthenium Catalysts: Revolutionizing Molecular Transformation through Benzylic C-H Oxidation

Discover how PNNP-ligated RuII complexes enable efficient benzylic C-H oxidation under mild conditions, transforming pharmaceutical synthesis and green chemistry.

Daniel Rose
Oct 13, 2025

Harnessing Light to Transform Stubborn Molecules: The Revolution of Visible-Light Photocatalysis

Discover how visible-light photocatalysis is revolutionizing the functionalization of unactivated C(sp³) substrates through sustainable and precise methods.

Benjamin Bennett
Aug 12, 2025

Popular Articles